Ontology highlight
ABSTRACT:
SUBMITTER: Haschemi A
PROVIDER: S-EPMC3370649 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Cell metabolism 20120601 6
Immune cells are somewhat unique in that activation responses can alter quantitative phenotypes upwards of 100,000-fold. To date little is known about the metabolic adaptations necessary to mount such dramatic phenotypic shifts. Screening for novel regulators of macrophage activation, we found nonprotein kinases of glucose metabolism among the most enriched classes of candidate immune modulators. We find that one of these, the carbohydrate kinase-like protein CARKL, is rapidly downregulated in v ...[more]