Ontology highlight
ABSTRACT:
SUBMITTER: Ouimet M
PROVIDER: S-EPMC4665799 | biostudies-other | 2015 Oct
REPOSITORIES: biostudies-other
Ouimet Mireille M Ediriweera Hasini N HN Gundra U Mahesh UM Sheedy Frederick J FJ Sheedy Frederick J FJ Ramkhelawon Bhama B Hutchison Susan B SB Rinehold Kaitlyn K van Solingen Coen C Fullerton Morgan D MD Cecchini Katharine K Rayner Katey J KJ Steinberg Gregory R GR Zamore Phillip D PD Fisher Edward A EA Loke P'ng P Moore Kathryn J KJ
The Journal of clinical investigation 20151026 12
Cellular metabolism is increasingly recognized as a controller of immune cell fate and function. MicroRNA-33 (miR-33) regulates cellular lipid metabolism and represses genes involved in cholesterol efflux, HDL biogenesis, and fatty acid oxidation. Here, we determined that miR-33-mediated disruption of the balance of aerobic glycolysis and mitochondrial oxidative phosphorylation instructs macrophage inflammatory polarization and shapes innate and adaptive immune responses. Macrophage-specific Mir ...[more]