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Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo.

ABSTRACT: The carbapenems imipenem and meropenem in combination with clavulanic acid reduced the bacterial burden in Mycobacterium tuberculosis-infected macrophages by 2 logs over 6 days. Despite poor stability in solution and a short half-life in rodents, treatment of chronically infected mice revealed significant reductions of bacterial burden in the lungs and spleens. Our results show that meropenem has activity in two in vivo systems, but stability and pharmacokinetics of long-term administration will offer significant challenges to clinical evaluation.

SUBMITTER: England K

PROVIDER: S-EPMC3370771 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature

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Meropenem-clavulanic acid shows activity against Mycobacterium tuberculosis in vivo.

England Kathleen K Boshoff Helena I M HI Arora Kriti K Weiner Danielle D Dayao Emmanuel E Schimel Daniel D Via Laura E LE Barry Clifton E CE

Antimicrobial agents and chemotherapy 20120326 6

The carbapenems imipenem and meropenem in combination with clavulanic acid reduced the bacterial burden in Mycobacterium tuberculosis-infected macrophages by 2 logs over 6 days. Despite poor stability in solution and a short half-life in rodents, treatment of chronically infected mice revealed significant reductions of bacterial burden in the lungs and spleens. Our results show that meropenem has activity in two in vivo systems, but stability and pharmacokinetics of long-term administration will ...[more]

PMID: 22450968

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