Ontology highlight
ABSTRACT:
SUBMITTER: Sao Emani C
PROVIDER: S-EPMC5913991 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Sao Emani C C Williams M J MJ Wiid I J IJ Baker B B Carolis C C
Antimicrobial agents and chemotherapy 20180327 4
The high acquisition rate of drug resistance by <i>Mycobacterium tuberculosis</i> necessitates the ongoing search for new drugs to be incorporated in the tuberculosis (TB) regimen. Compounds used for the treatment of other diseases have the potential to be repurposed for the treatment of TB. In this study, a high-throughput screening of compounds against thiol-deficient <i>Mycobacterium smegmatis</i> strains and subsequent validation with thiol-deficient <i>M. tuberculosis</i> strains revealed t ...[more]