Ontology highlight
ABSTRACT:
SUBMITTER: Maskiewicz R
PROVIDER: S-EPMC3370808 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Maskiewicz Richard R Bobardt Michael M Chatterji Udayan U Gunaseelan Simi S Dezzutti Charlene S CS Penin Francois F Gallay Philippe A PA
Antimicrobial agents and chemotherapy 20120319 6
We have identified a short amphipathic helical peptide, called C5A, which exhibits potent microbicidal activities in vitro and which offers protection from vaginal HIV transmission in vivo in a humanized mouse model. However, there are many obstacles to overcome before C5A can be considered a true microbicidal candidate. First, it must be stabilized against enzymatic degradation in a continuously warm and moist environment. Second, it must be delivered in a controlled manner to achieve long-term ...[more]