Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC3934007 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Li Jiayang J Li Xinming X Kuang Yi Y Gao Yuan Y Du Xuewen X Shi Junfeng J Xu Bing B
Advanced healthcare materials 20130425 12
None of the clinical trials of anti-HIV gels based on conventional polymers or lipid emulsions has been successful, suggesting the need of new molecular design of the anti-HIV gels. This paper reports the conversion of anti-HIV prodrugs into self-delivery supramolecular hydrogels. By covalently conjugating reverse transcriptase inhibitors to a versatile self-assembly motif, the hydrogelators that self-assemble to form supramolecular nanofibers as the matrices of hydrogels in a weak acidic condit ...[more]