Rapamycin attenuates aggressive behavior in a rat model of pilocarpine-induced epilepsy.
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ABSTRACT:
SUBMITTER: Huang X
PROVIDER: S-EPMC3371158 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
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Rapamycin attenuates aggressive behavior in a rat model of pilocarpine-induced epilepsy.
Huang X X McMahon J J Huang Y Y
Neuroscience 20120420
Psychiatric disorders are fairly common comorbidities of epilepsy in humans. Following pilocarpine-induced status epilepticus (SE), experimental animals not only developed spontaneous recurrent seizures, but also exhibited significantly elevated levels of aggressive behavior. The cellular and molecular mechanism triggering these behavioral alterations remains unclear. In the present study, we found that aggression is positively correlated with development of spontaneous seizures. Treatment with ...[more]
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