Metformin monotherapy in youth with recent onset type 2 diabetes: experience from the prerandomization run-in phase of the TODAY study.

ABSTRACT:

Background

TODAY (Treatment Options for type 2 Diabetes in Adolescents and Youth) is a federally funded multicenter randomized clinical trial comparing three treatments of youth onset type 2 diabetes.

Objective

To describe the experience of youth participating in a 2-6 month run-in period in preparation for randomization into TODAY.

Subjects

An ethnically diverse sample of 927 youth, 65.4% females, aged 13.7 ± 2.0 yr old, with type 2 diabetes for a median of 2 months (0.7-7.8 months, 25th-75th percentiles).

Methods

A run-in period was conducted to achieve HbA1c <8% with metformin monotherapy and diabetes education, and to evaluate adherence to pill taking, visit attendance, and other procedures.

Results

At entry, mean body mass index (BMI) and z-BMI were

SUBMITTER: Laffel L 

PROVIDER: S-EPMC3371323 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature