RASSF1 Polymorphisms in Cancer.
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ABSTRACT:
SUBMITTER: Gordon M
PROVIDER: S-EPMC3371342 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
RASSF1 Polymorphisms in Cancer.
Gordon Marilyn M El-Kalla Mohamed M Baksh Shairaz S
Molecular biology international 20120531
Ras association domain family 1A (RASSF1A) is one of the most epigenetically silenced elements in human cancers. Localized on chromosome 3, it has been demonstrated to be a bone fide tumor suppressor influencing cell cycle events, microtubule stability, apoptosis, and autophagy. Although it is epigenetically silenced by promoter-specific methylation in cancers, several somatic nucleotide changes (polymorphisms) have been identified in RASSF1A in tissues from cancer patients. We speculate that bo ...[more]
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