Ontology highlight
ABSTRACT:
SUBMITTER: Kashuba VI
PROVIDER: S-EPMC2684631 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Kashuba Vladimir I VI Pavlova Tatiana V TV Grigorieva Elvira V EV Kutsenko Alexey A Yenamandra Surya Pavan SP Li Jingfeng J Wang Fuli F Protopopov Alexei I AI Zabarovska Veronika I VI Senchenko Vera V Haraldson Klas K Eshchenko Tatiana T Kobliakova Julia J Vorontsova Olga O Kuzmin Igor I Braga Eleonora E Blinov Vladimir M VM Kisselev Lev L LL Zeng Yi-Xin YX Ernberg Ingemar I Lerman Michael I MI Klein George G Zabarovsky Eugene R ER
PloS one 20090529 5
<h4>Background</h4>Many different genetic alterations are observed in cancer cells. Individual cancer genes display point mutations such as base changes, insertions and deletions that initiate and promote cancer growth and spread. Somatic hypermutation is a powerful mechanism for generation of different mutations. It was shown previously that somatic hypermutability of proto-oncogenes can induce development of lymphomas.<h4>Methodology/principal findings</h4>We found an exceptionally high incide ...[more]