Ontology highlight
ABSTRACT:
SUBMITTER: Smith GR
PROVIDER: S-EPMC3372252 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Microbiology and molecular biology reviews : MMBR 20120601 2
The repair of DNA double-strand breaks (DSBs) is essential for cell viability and important for homologous genetic recombination. In enteric bacteria such as Escherichia coli, the major pathway of DSB repair requires the RecBCD enzyme, a complex helicase-nuclease regulated by a simple unique DNA sequence called Chi. How Chi regulates RecBCD has been extensively studied by both genetics and biochemistry, and two contrasting mechanisms to generate a recombinogenic single-stranded DNA tail have bee ...[more]