Ontology highlight
ABSTRACT:
SUBMITTER: Im SS
PROVIDER: S-EPMC3372266 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Im Seung-Soon SS Osborne Timothy F TF
Molecular and cellular biology 20120409 12
Sterol regulatory element binding protein (SREBP) transcription factors activate genes of lipid metabolism, but recent studies indicate they also activate genes involved in other physiologic processes, suggesting that SREPBs have evolved to connect lipid metabolism with diverse physiologic responses. There are three major mammalian SREBPs, and the 1a isoform is specifically expressed at very high levels in macrophages, where a recent study showed that it couples lipid synthesis to the proinflamm ...[more]