Ontology highlight
ABSTRACT:
SUBMITTER: Soler-Llavina GJ
PROVIDER: S-EPMC3741667 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Soler-Llavina Gilberto J GJ Arstikaitis Pamela P Morishita Wade W Ahmad Mohiuddin M Südhof Thomas C TC Malenka Robert C RC
Neuron 20130801 3
Leucine-rich repeat transmembrane proteins (LRRTMs) are synaptic cell adhesion molecules that trigger excitatory synapse assembly in cultured neurons and influence synaptic function in vivo, but their role in synaptic plasticity is unknown. shRNA-mediated knockdown (KD) of LRRTM1 and LRRTM2 in vivo in CA1 pyramidal neurons of newborn mice blocked long-term potentiation (LTP) in acute hippocampal slices. Molecular replacement experiments revealed that the LRRTM2 extracellular domain is sufficient ...[more]