Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC3372943 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Wang Yuanjia Y Huang Chiahui C
Biostatistics (Oxford, England) 20110919 3
In a family-based genetic study such as the Framingham Heart Study (FHS), longitudinal trait measurements are recorded on subjects collected from families. Observations on subjects from the same family are correlated due to shared genetic composition or environmental factors such as diet. The data have a 3-level structure with measurements nested in subjects and subjects nested in families. We propose a semiparametric variance components model to describe phenotype observed at a time point as th ...[more]