Ontology highlight
ABSTRACT:
SUBMITTER: Lee J
PROVIDER: S-EPMC3374076 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Lee J J Hong Y K YK Jeon G S GS Hwang Y J YJ Kim K Y KY Seong K H KH Jung M-K MK Picketts D J DJ Kowall N W NW Cho K S KS Ryu H H
Cell death and differentiation 20120113 7
Aberrant chromatin remodeling is involved in the pathogenesis of Huntington's disease (HD) but the mechanism is not known. Herein, we report that mutant huntingtin (mtHtt) induces the transcription of alpha thalassemia/mental retardation X linked (ATRX), an ATPase/helicase and SWI/SNF-like chromatin remodeling protein via Cdx-2 activation. ATRX expression was elevated in both a cell line model and transgenic model of HD, and Cdx-2 occupancy of the ATRX promoter was increased in HD. Induction of ...[more]