Ontology highlight
ABSTRACT:
SUBMITTER: Tumanov AV
PROVIDER: S-EPMC3375029 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Tumanov Alexei V AV Koroleva Ekaterina P EP Guo Xiaohuan X Wang Yugang Y Kruglov Andrei A Nedospasov Sergei S Fu Yang-Xin YX
Cell host & microbe 20110701 1
Innate lymphoid cells (ILCs) have emerged as important players, regulating the balance between protective immunity and immunopathology at mucosal surfaces. However, mechanisms that regulate ILCs' effector functions during mucosal pathogenic challenge are poorly defined. Using mice infected with the natural mouse enteric pathogen Citrobacter rodentium, we demonstrate that lymphotoxin (LT) is essential for IL-22 production by intestinal ILCs. Blocking of LTβR signaling dramatically reduced intesti ...[more]