Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC6123485 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Zhang Yuan Y Kim Tae-Jin TJ Wroblewska Joanna A JA Tesic Vera V Upadhyay Vaibhav V Weichselbaum Ralph R RR Tumanov Alexei V AV Tang Hong H Guo Xiaohuan X Tang Haidong H Fu Yang-Xin YX
Cellular & molecular immunology 20170605 7
Splenomegaly is a well-known phenomenon typically associated with inflammation. However, the underlying cause of this phenotype has not been well characterized. Furthermore, the splenomegaly phenotype seen in lymphotoxin (LT) signaling-deficient mice is characterized by increased numbers of splenocytes and splenic neutrophils. Splenomegaly, as well as the related phenotype of increased lymphocyte counts in non-lymphoid tissues, is thought to result from the absence of secondary lymphoid tissues ...[more]