The role of the mouse y chromosome on susceptibility to testicular germ cell tumors.
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ABSTRACT:
SUBMITTER: Anderson PD
PROVIDER: S-EPMC3375048 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
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The role of the mouse y chromosome on susceptibility to testicular germ cell tumors.
Anderson Philip D PD Lam Man-Yee MY Poirier Christophe C Bishop Colin E CE Nadeau Joseph H JH
Cancer research 20090407 8
Testicular germ cell tumors (TGCT) are sex limited, occurring only in males with a Y chromosome. Recently, the gr/gr deletion on the human Y chromosome was associated with increased risk of TGCTs. In addition, the presence of Y chromosome sequences is associated with TGCTs in cases of gonadal dysgenesis. TGCTs in strain 129 males recapitulate many aspects of testicular cancer in human infants and can be used to evaluate the role of the Y chromosome in TGCT risk. We used chromosome substitution s ...[more]
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