Ontology highlight
ABSTRACT:
SUBMITTER: Ullah U
PROVIDER: S-EPMC3376453 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Ullah Ubaid U Tripathi Parul P Lahesmaa Riitta R Rao Kanury V S KV
Scientific reports 20120618
In this study we show that IL-4 is crucial during reinforcement window of human Th2 differentiation for optimal Th2 development. We have also shown here that during this stage, IL-4 helps in cellular decision-making process of differentiation versus proliferation. We have combined computational and experimental methods to analyze Th2 transcription network to name novel players of the process of Th2 differentiation. Here we report that LIF through STAT3 negatively regulates Th2 differentiation. T ...[more]