Ontology highlight
ABSTRACT:
SUBMITTER: Sourisseau T
PROVIDER: S-EPMC3377280 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Sourisseau Tony T Maniotis Despina D McCarthy Afshan A Tang Chan C Lord Christopher J CJ Ashworth Alan A Linardopoulos Spiros S
EMBO molecular medicine 20100401 4
The protein kinase Aurora-A is a major regulator of the cell cycle that orchestrates mitotic entry and is required for the assembly of a functional mitotic spindle. Overexpression of Aurora-A has been strongly linked with oncogenesis and this has led to considerable efforts at therapeutic targeting of the kinase activity of this protein. However, the exact mechanism by which Aurora-A promotes oncogenesis remains unclear. Here, we show that Aurora-A modulates the repair of DNA double-strand break ...[more]