Ontology highlight
ABSTRACT:
SUBMITTER: Yuan CC
PROVIDER: S-EPMC3377377 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Yuan Chih-Chi CC Matthews Adam G W AG Jin Yi Y Chen Chang Feng CF Chapman Brad A BA Ohsumi Toshiro K TK Glass Karen C KC Kutateladze Tatiana G TG Borowsky Mark L ML Struhl Kevin K Oettinger Marjorie A MA
Cell reports 20120201 2
The preferential in vitro interaction of the PHD finger of RAG2, a subunit of the V(D)J recombinase, with histone H3 tails simultaneously trimethylated at lysine 4 and symmetrically dimethylated at arginine 2 (H3R2me2sK4me3) predicted the existence of the previously unknown histone modification H3R2me2s. Here, we report the in vivo identification of H3R2me2s . Consistent with the binding specificity of the RAG2 PHD finger, high levels of H3R2me2sK4me3 are found at antigen receptor gene segments ...[more]