Ontology highlight
ABSTRACT:
SUBMITTER: Royer L
PROVIDER: S-EPMC3377704 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Royer Loic L Reimann Matthias M Stewart A Francis AF Schroeder Michael M
PloS one 20120618 6
With the advent of large-scale protein interaction studies, there is much debate about data quality. Can different noise levels in the measurements be assessed by analyzing network structure? Because proteomic regulation is inherently co-operative, modular and redundant, it is inherently compressible when represented as a network. Here we propose that network compression can be used to compare false positive and false negative noise levels in protein interaction networks. We validate this hypoth ...[more]