Ontology highlight
ABSTRACT:
SUBMITTER: Kumar T
PROVIDER: S-EPMC7550192 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Kumar Tarun T Blondel Leo L Extavour Cassandra G CG
eLife 20200909
Understanding the genetic regulation of organ structure is a fundamental problem in developmental biology. Here, we use egg-producing structures of insect ovaries, called ovarioles, to deduce systems-level gene regulatory relationships from quantitative functional genetic analysis. We previously showed that Hippo signalling, a conserved regulator of animal organ size, regulates ovariole number in <i>Drosophila melanogaster</i>. To comprehensively determine how Hippo signalling interacts with oth ...[more]