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ABSTRACT:
SUBMITTER: Kucukelbir A
PROVIDER: S-EPMC3377842 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Kucukelbir Alp A Sigworth Fred J FJ Tagare Hemant D HD
Journal of structural biology 20120501 1
Traditional single particle reconstruction methods use either the Fourier or the delta function basis to represent the particle density map. This paper proposes a more flexible algorithm that adaptively chooses the basis based on the data. Because the basis adapts to the data, the reconstruction resolution and signal-to-noise ratio (SNR) is improved compared to a reconstruction with a fixed basis. Moreover, the algorithm automatically masks the particle, thereby separating it from the background ...[more]