Ontology highlight
ABSTRACT:
SUBMITTER: Choi O
PROVIDER: S-EPMC3378644 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Choi Onjee O Heathcote Dean A DA Ho Ka-Kei KK Müller Phillip J PJ Ghani Hazim H Lam Eric W-F EW Ashton-Rickardt Philip G PG Rutschmann Sophie S
Journal of immunology (Baltimore, Md. : 1950) 20120309 8
The homeostasis of the immune system is tightly controlled by both cell-extrinsic and -intrinsic mechanisms. These regulators, not all known to date, drive cells in and out of quiescence when and where required to allow the immune system to function. In this article, we describe a deficiency in deoxycytidine kinase (DCK), one of the major enzymes of the nucleoside salvage pathway, which affects peripheral T cell homeostatic proliferation and survival. As a result of an N-ethyl-N-nitrosourea-indu ...[more]