Ontology highlight
ABSTRACT:
SUBMITTER: Ogden KM
PROVIDER: S-EPMC3378758 | biostudies-literature | 2012 Sep 15-30
REPOSITORIES: biostudies-literature
Virology 20120602 1-2
The rotavirus RNA-dependent RNA polymerase (RdRp), VP1, contains canonical RdRp motifs and a priming loop that is hypothesized to undergo conformational rearrangements during RNA synthesis. In the absence of viral core shell protein VP2, VP1 fails to interact stably with divalent cations or nucleotides and has a retracted priming loop. To identify residues of potential import to nucleotide and divalent cation stabilization, we aligned VP1 of divergent rotaviruses and the structural homolog reovi ...[more]