Ontology highlight
ABSTRACT:
SUBMITTER: Vincent DF
PROVIDER: S-EPMC3378851 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Vincent David F DF Gout Johann J Chuvin Nicolas N Arfi Vanessa V Pommier Roxane M RM Bertolino Philippe P Jonckheere Nicolas N Ripoche Doriane D Kaniewski Bastien B Martel Sylvie S Langlois Jean-Baptiste JB Goddard-Léon Sophie S Colombe Amélie A Janier Marc M Van Seuningen Isabelle I Losson Régine R Valcourt Ulrich U Treilleux Isabelle I Dubus Pierre P Bardeesy Nabeel N Bartholin Laurent L
The American journal of pathology 20120331 6
Transcriptional intermediary factor 1γ (TIF1γ; alias, TRIM33/RFG7/PTC7/ectodermin) belongs to an evolutionarily conserved family of nuclear factors that have been implicated in stem cell pluripotency, embryonic development, and tumor suppression. TIF1γ expression is markedly down-regulated in human pancreatic tumors, and Pdx1-driven Tif1γ inactivation cooperates with the Kras(G12D) oncogene in the mouse pancreas to induce intraductal papillary mucinous neoplasms. In this study, we report that ag ...[more]