Ontology highlight
ABSTRACT:
SUBMITTER: Roth S
PROVIDER: S-EPMC3380033 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
PloS one 20120620 6
Adult stem cell niches are often co-inhabited by cycling and quiescent stem cells. In the intestine, lineage tracing has identified Lgr5(+) cells as frequently cycling stem cells, whereas Bmi1(+), mTert(+), Hopx(+) and Lrig1(+) cells appear to be more quiescent. Here, we have applied a non-mutagenic and cell cycle independent approach to isolate and characterize small intestinal label-retaining cells (LRCs) persisting in the lower third of the crypt of Lieberkühn for up to 100 days. LRCs do not ...[more]