IL-33 family members and asthma - bridging innate and adaptive immune responses.
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ABSTRACT:
SUBMITTER: Lloyd CM
PROVIDER: S-EPMC3380518 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Publications
IL-33 family members and asthma - bridging innate and adaptive immune responses.
Current opinion in immunology 20101109 6
The discovery of IL-33 as the ligand for the orphan Th2 associated receptor ST2 has uncovered a whole range of different avenues for this pathway. Although the extracellular functions of ST2 as a marker for Th2 cell and mast cell activity were well defined, the complexities of IL-33 regulation, nuclear function and secretion are only just being realised. The well documented expression pattern of ST2 has identified a role for the IL-33/ST2 axis in the classical Th2 cell and mast cell driven patho ...[more]
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