Effects of age and ?-amyloid on cognitive changes in normal elderly people.
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ABSTRACT:
SUBMITTER: Oh H
PROVIDER: S-EPMC3381075 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Publications
Effects of age and β-amyloid on cognitive changes in normal elderly people.
Oh Hwamee H Madison Cindee C Haight Thaddeus J TJ Markley Candace C Jagust William J WJ
Neurobiology of aging 20120317 12
Age-related decline is common in multiple cognitive domains. β-amyloid (Aβ) deposition, a pathological hallmark of Alzheimer's disease, is also associated with cognitive changes in many older people. In this study, we examined a wide range of cognitive function in order to differentiate the effect of age and Aβ on cognition during aging. Using positron emission tomography (PET) imaging with the radiotracer Pittsburgh Compound B (PIB), we classified normal older subjects as High PIB-Old and Low P ...[more]
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