Circulating microRNAs disclose biology of normal cognitive function in healthy elderly people - a discovery twin study.
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ABSTRACT:
SUBMITTER: Mengel-From J
PROVIDER: S-EPMC6117263 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
Circulating microRNAs disclose biology of normal cognitive function in healthy elderly people - a discovery twin study.
Mengel-From Jonas J Feddersen Søren S Halekoh Ulrich U Heegaard Niels H H NHH McGue Matt M Christensen Kaare K Tan Qihua Q Christiansen Lene L
European journal of human genetics : EJHG 20180502 9
Neurobiology is regulated by miRNA. Here circulating plasma miRNAs were assayed on a 754 miRNA OpenArray platform using 90 monozygotic elderly twins (73-95 year of age) and associated with mini mental state examination (MMSE) and a five-component cognitive score (CCS) in an explorative study. Both ordinary individual and twin-pair analyses were performed with level of cognitive scores. Candidate miRNAs were further associated with cognitive decline over 10 years using up to six repeated assessme ...[more]
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