Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC3381192 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Li Xiaofeng X Zhang Rong R Draheim Kyle M KM Liu Weizhi W Calderwood David A DA Boggon Titus J TJ
The Journal of biological chemistry 20120510 26
Cerebral cavernous malformations (CCMs) affect 0.1-0.5% of the population resulting in leaky vasculature and severe neurological defects. KRIT1 (Krev interaction trapped-1) mutations associate with ∼40% of familial CCMs. KRIT1 is an effector of Ras-related protein 1 (Rap1) GTPase. Rap1 relocalizes KRIT1 from microtubules to cell membranes to impact integrin activation, potentially important for CCM pathology. We report the 1.95 Å co-crystal structure of KRIT1 FERM domain in complex with Rap1. Ra ...[more]