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MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis.


ABSTRACT: Dysregulation of the T cell-dependent Ab response can lead to numerous immunological disorders, ranging from systemic lupus erythematosus to B cell lymphomas. Cellular processes governed by MHC class II proteins play a major role in this response and its dysregulation. The extent to which processes controlled by the diverse family of MHC class I proteins impact such autoimmune and neoplastic disorders, however, is less clear. In this study, we genetically dissect the contributions of individual MHC class I family members and the pathological processes under their control in the systemic lupus erythematosus-like disease of BXSB.Yaa mice and B cell lymphomagenesis of SJL mice. This study reveals a powerful repressive regulatory axis comprised of MHC class I-dependent CD8(+) T cells and NK cells. These results indicate that the predominant role of the MHC class I protein family in such immunological disorders is to protect from more aggressive diseases.

SUBMITTER: McPhee CG 

PROVIDER: S-EPMC3381364 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

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MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis.

McPhee Caroline G CG   Sproule Thomas J TJ   Shin Dong-Mi DM   Bubier Jason A JA   Schott William H WH   Steinbuck Martin P MP   Avenesyan Lia L   Morse Herbert C HC   Roopenian Derry C DC  

Journal of immunology (Baltimore, Md. : 1950) 20110930 9


Dysregulation of the T cell-dependent Ab response can lead to numerous immunological disorders, ranging from systemic lupus erythematosus to B cell lymphomas. Cellular processes governed by MHC class II proteins play a major role in this response and its dysregulation. The extent to which processes controlled by the diverse family of MHC class I proteins impact such autoimmune and neoplastic disorders, however, is less clear. In this study, we genetically dissect the contributions of individual  ...[more]

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