Ontology highlight
ABSTRACT:
SUBMITTER: McPhee CG
PROVIDER: S-EPMC3381364 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
McPhee Caroline G CG Sproule Thomas J TJ Shin Dong-Mi DM Bubier Jason A JA Schott William H WH Steinbuck Martin P MP Avenesyan Lia L Morse Herbert C HC Roopenian Derry C DC
Journal of immunology (Baltimore, Md. : 1950) 20110930 9
Dysregulation of the T cell-dependent Ab response can lead to numerous immunological disorders, ranging from systemic lupus erythematosus to B cell lymphomas. Cellular processes governed by MHC class II proteins play a major role in this response and its dysregulation. The extent to which processes controlled by the diverse family of MHC class I proteins impact such autoimmune and neoplastic disorders, however, is less clear. In this study, we genetically dissect the contributions of individual ...[more]