Ontology highlight
ABSTRACT:
SUBMITTER: Novobrantseva TI
PROVIDER: S-EPMC3381593 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Molecular therapy. Nucleic acids 20120124
Leukocytes are central regulators of inflammation and the target cells of therapies for key diseases, including autoimmune, cardiovascular, and malignant disorders. Efficient in vivo delivery of small interfering RNA (siRNA) to immune cells could thus enable novel treatment strategies with broad applicability. In this report, we develop systemic delivery methods of siRNA encapsulated in lipid nanoparticles (LNP) for durable and potent in vivo RNA interference (RNAi)-mediated silencing in myeloid ...[more]