Ontology highlight
ABSTRACT:
SUBMITTER: John M
PROVIDER: S-EPMC3019095 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
John Matthias M Constien Rainer R Akinc Akin A Goldberg Michael M Moon Young-Ah YA Spranger Martina M Hadwiger Philipp P Soutschek Jürgen J Vornlocher Hans-Peter HP Manoharan Muthiah M Stoffel Markus M Langer Robert R Anderson Daniel G DG Horton Jay D JD Koteliansky Victor V Bumcrot David D
Nature 20070926 7163
Systemic administration of synthetic small interfering RNAs (siRNAs) effectively silences hepatocyte gene expression in rodents and primates. Whether or not in vivo gene silencing by synthetic siRNA can disrupt the endogenous microRNA (miRNA) pathway remains to be addressed. Here we show that effective target-gene silencing in the mouse and hamster liver can be achieved by systemic administration of synthetic siRNA without any demonstrable effect on miRNA levels or activity. Indeed, siRNA target ...[more]