Ontology highlight
ABSTRACT:
SUBMITTER: Steinberg MW
PROVIDER: S-EPMC3381650 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Steinberg Marcos W MW Cheung Timothy C TC Ware Carl F CF
Immunological reviews 20111101 1
The tumor necrosis factor (TNF) receptor superfamily member herpesvirus entry mediator (HVEM) (TNFRSF14) regulates T-cell immune responses by activating both inflammatory and inhibitory signaling pathways. HVEM acts as both a receptor for the canonical TNF-related ligands, LIGHT [lymphotoxin-like, exhibits inducible expression, and competes with herpes simplex virus glycoprotein D for HVEM, a receptor expressed on T lymphocytes] and lymphotoxin-α, and as a ligand for the immunoglobulin superfami ...[more]