Ontology highlight
ABSTRACT:
SUBMITTER: Sedy JR
PROVIDER: S-EPMC3702646 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Šedý John R JR Bjordahl Ryan L RL Bekiaris Vasileios V Macauley Matthew G MG Ware Brian C BC Norris Paula S PS Lurain Nell S NS Benedict Chris A CA Ware Carl F CF
Journal of immunology (Baltimore, Md. : 1950) 20130612 2
Lymphocyte activation is regulated by costimulatory and inhibitory receptors, of which both B and T lymphocyte attenuator (BTLA) and CD160 engage herpesvirus entry mediator (HVEM). Notably, it remains unclear how HVEM functions with each of its ligands during immune responses. In this study, we show that HVEM specifically activates CD160 on effector NK cells challenged with virus-infected cells. Human CD56(dim) NK cells were costimulated specifically by HVEM but not by other receptors that share ...[more]