Ontology highlight
ABSTRACT:
SUBMITTER: Wilhelm JC
PROVIDER: S-EPMC3382119 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Wilhelm Jennifer C JC Xu Mei M Cucoranu Delia D Chmielewski Sarah S Holmes Tiffany T Lau Kelly Shukkwan KS Bassell Gary J GJ English Arthur W AW
The Journal of neuroscience : the official journal of the Society for Neuroscience 20120401 14
After peripheral nerve injury, neurotrophins play a key role in the regeneration of damaged axons that can be augmented by exercise, although the distinct roles played by neurons and Schwann cells are unclear. In this study, we evaluated the requirement for the neurotrophin, brain-derived neurotrophic factor (BDNF), in neurons and Schwann cells for the regeneration of peripheral axons after injury. Common fibular or tibial nerves in thy-1-YFP-H mice were cut bilaterally and repaired using a graf ...[more]