Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC8887133 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Li Yuhuan Y Kang Sangjo S Halawani Dalia D Wang Yiqun Y Junqueira Alves Chrystian C Ramakrishnan Aarthi A Estill Molly M Shen Li L Li Fengtao F He Xijing X Friedel Roland H RH Zou Hongyan H
Genes & development 20220127 3-4
The regeneration of peripheral nerves is guided by regeneration tracks formed through an interplay of many cell types, but the underlying signaling pathways remain unclear. Here, we demonstrate that macrophages are mobilized ahead of Schwann cells in the nerve bridge after transection injury to participate in building regeneration tracks. This requires the function of guidance receptor Plexin-B2, which is robustly up-regulated in infiltrating macrophages in injured nerves. Conditional deletion o ...[more]