Ontology highlight
ABSTRACT: Background
Earlier analyses within the EPIC study showed that dietary fibre intake was inversely associated with colorectal cancer risk, but results from some large cohort studies do not support this finding. We explored whether the association remained after longer follow-up with a near threefold increase in colorectal cancer cases, and if the association varied by gender and tumour location.Methodology/principal findings
After a mean follow-up of 11.0 years, 4,517 incident cases of colorectal cancer were documented. Total, cereal, fruit, and vegetable fibre intakes were estimated from dietary questionnaires at baseline. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models stratified by age, sex, and centre, and adjusted for total energy intake, body mass index, physical activity, smoking, education, menopausal status, hormone replacement therapy, oral contraceptive use, and intakes of alcohol, folate, red and processed meats, and calcium. After multivariable adjustments, total dietary fibre was inversely associated with colorectal cancer (HR per 10 g/day increase in fibre 0.87, 95% CI: 0.79-0.96). Similar linear associations were observed for colon and rectal cancers. The association between total dietary fibre and risk of colorectal cancer risk did not differ by age, sex, or anthropometric, lifestyle, and dietary variables. Fibre from cereals and fibre from fruit and vegetables were similarly associated with colon cancer; but for rectal cancer, the inverse association was only evident for fibre from cereals.Conclusions/significance
Our results strengthen the evidence for the role of high dietary fibre intake in colorectal cancer prevention.
SUBMITTER: Murphy N
PROVIDER: S-EPMC3382210 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Murphy Neil N Norat Teresa T Ferrari Pietro P Jenab Mazda M Bueno-de-Mesquita Bas B Skeie Guri G Dahm Christina C CC Overvad Kim K Olsen Anja A Tjønneland Anne A Clavel-Chapelon Françoise F Boutron-Ruault Marie Christine MC Racine Antoine A Kaaks Rudolf R Teucher Birgit B Boeing Heiner H Bergmann Manuela M MM Trichopoulou Antonia A Trichopoulos Dimitrios D Lagiou Pagona P Palli Domenico D Pala Valeria V Panico Salvatore S Tumino Rosario R Vineis Paolo P Siersema Peter P van Duijnhoven Franzel F Peeters Petra H M PH Hjartaker Anette A Engeset Dagrun D González Carlos A CA Sánchez Maria-José MJ Dorronsoro Miren M Navarro Carmen C Ardanaz Eva E Quirós José R JR Sonestedt Emily E Ericson Ulrika U Nilsson Lena L Palmqvist Richard R Khaw Kay-Tee KT Wareham Nick N Key Timothy J TJ Crowe Francesca L FL Fedirko Veronika V Wark Petra A PA Chuang Shu-Chun SC Riboli Elio E
PloS one 20120622 6
<h4>Background</h4>Earlier analyses within the EPIC study showed that dietary fibre intake was inversely associated with colorectal cancer risk, but results from some large cohort studies do not support this finding. We explored whether the association remained after longer follow-up with a near threefold increase in colorectal cancer cases, and if the association varied by gender and tumour location.<h4>Methodology/principal findings</h4>After a mean follow-up of 11.0 years, 4,517 incident case ...[more]