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Perforin-dependent CD4+ T-cell cytotoxicity contributes to control a murine poxvirus infection.

ABSTRACT: CD4(+) T cells are generally regarded as helpers and regulators of the immune response. Although cytolytic CD4(+) T cells have been described, whether those generated during the course of a viral infection play a role in virus control remains unknown. Here we show that during acute infection with ectromelia virus, the mouse homolog of the human virus of smallpox, large numbers of CD4(+) T cells in the draining lymph node and liver of resistant mice have a cytotoxic phenotype. We also show that these cells kill targets in vivo in a perforin-dependent manner and that mice with specific deficiency of perforin in CD4(+) T cells have impaired virus control. Thus, perforin-dependent CD4(+) T-cell killing of infected cells is an important mechanism of antiviral defense.

SUBMITTER: Fang M

PROVIDER: S-EPMC3382508 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature

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Perforin-dependent CD4+ T-cell cytotoxicity contributes to control a murine poxvirus infection.

Fang Min M Siciliano Nicholas A NA Hersperger Adam R AR Roscoe Felicia F Hu Angela A Ma Xueying X Shamsedeen Ahamed R AR Eisenlohr Laurence C LC Sigal Luis J LJ

Proceedings of the National Academy of Sciences of the United States of America 20120604 25

CD4(+) T cells are generally regarded as helpers and regulators of the immune response. Although cytolytic CD4(+) T cells have been described, whether those generated during the course of a viral infection play a role in virus control remains unknown. Here we show that during acute infection with ectromelia virus, the mouse homolog of the human virus of smallpox, large numbers of CD4(+) T cells in the draining lymph node and liver of resistant mice have a cytotoxic phenotype. We also show that t ...[more]

PMID: 22665800

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