Ontology highlight
ABSTRACT:
SUBMITTER: Zhong J
PROVIDER: S-EPMC3382619 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Zhong Jiateng J Kong Xiaoxia X Zhang Hongyu H Yu Chunyan C Xu Ye Y Kang Jinsong J Yu Huimei H Yi Haowei H Yang Xiaochun X Sun Liankun L
PloS one 20120625 6
CLIC4/mtCLIC, a chloride intracellular channel protein, localizes to mitochondria, endoplasmic reticulum (ER), nucleus and cytoplasm, and participates in the apoptotic response to stress. Apoptosis and autophagy, the main types of the programmed cell death, seem interconnected under certain stress conditions. However, the role of CLIC4 in autophagy regulation has yet to be determined. In this study, we demonstrate upregulation and nuclear translocation of the CLIC4 protein following starvation i ...[more]