CASK interacts with PMCA4b and JAM-A on the mouse sperm flagellum to regulate Ca2+ homeostasis and motility.
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ABSTRACT:
SUBMITTER: Aravindan RG
PROVIDER: S-EPMC3383836 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
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CASK interacts with PMCA4b and JAM-A on the mouse sperm flagellum to regulate Ca2+ homeostasis and motility.
Aravindan Rolands G RG Fomin Victor P VP Naik Ulhas P UP Modelski Mark J MJ Naik Meghna U MU Galileo Deni S DS Duncan Randall L RL Martin-Deleon Patricia A PA
Journal of cellular physiology 20120801 8
Deletion of the highly conserved gene for the major Ca(2+) efflux pump, Plasma membrane calcium/calmodulin-dependent ATPase 4b (Pmca4b), in the mouse leads to loss of progressive and hyperactivated sperm motility and infertility. Here we first demonstrate that compared to wild-type (WT), Junctional adhesion molecule-A (Jam-A) null sperm, previously shown to have motility defects and an abnormal mitochondrial phenotype reminiscent of that seen in Pmca4b nulls, exhibit reduced (P < 0.001) ATP leve ...[more]
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