Ontology highlight
ABSTRACT:
SUBMITTER: Dienemann C
PROVIDER: S-EPMC3384007 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Dienemann Christian C Bøggild Andreas A Winther Kristoffer S KS Gerdes Kenn K Brodersen Ditlev E DE
Journal of molecular biology 20111020 5
Toxin-antitoxin (TA) loci are common in archaea and prokaryotes and allow cells to rapidly adapt to changing environmental conditions through release of active regulators of metabolism. Many toxins are endonucleases that target cellular mRNA and tRNAs, while the antitoxins tightly wrap around the toxins to inhibit them under normal circumstances. The antitoxins also bind to operators in the promoter regions of the cognate TA operon and thereby regulate transcription. For enteric vapBC TA loci, t ...[more]