Heat shock protein 90 inhibition: rationale and clinical potential.
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ABSTRACT:
SUBMITTER: Den RB
PROVIDER: S-EPMC3384095 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Publications
Heat shock protein 90 inhibition: rationale and clinical potential.
Therapeutic advances in medical oncology 20120701 4
Heat shock protein 90 (HSP90) is a molecular chaperone protein essential for cellular survival. Functionally, HSPs promote proper protein folding, prevent misfolding, and restore three-dimensional protein structure which is critical following toxic cellular stresses. Recently, targeting HSP90 pharmacologically has gained traction in cancer therapy. Oncogenic cells depend on their ability to withstand endogenous (anoxia, nutrient deprivation, pH changes, and deranged signaling pathways) and exoge ...[more]
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