Ontology highlight
ABSTRACT:
SUBMITTER: Fang B
PROVIDER: S-EPMC3384313 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Fang Bin B Mane-Padros Daniel D Bolotin Eugene E Jiang Tao T Sladek Frances M FM
Nucleic acids research 20120301 12
Nuclear receptors (NRs) regulate gene expression by binding specific DNA sequences consisting of AG[G/T]TCA or AGAACA half site motifs in a variety of configurations. However, those motifs/configurations alone do not adequately explain the diversity of NR function in vivo. Here, a systematic examination of DNA binding specificity by protein-binding microarrays (PBMs) of three closely related human NRs--HNF4α, retinoid X receptor alpha (RXRα) and COUPTF2--reveals an HNF4-specific binding motif (H ...[more]