Ontology highlight
ABSTRACT:
SUBMITTER: Rank KC
PROVIDER: S-EPMC3384419 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Rank Katherine C KC Chen Chun Ju CJ Cope Julia J Porche Ken K Hoenger Andreas A Gilbert Susan P SP Rayment Ivan I
The Journal of cell biology 20120601 7
Kinesin-14 motors generate microtubule minus-end-directed force used in mitosis and meiosis. These motors are dimeric and operate with a nonprocessive powerstroke mechanism, but the role of the second head in motility has been unclear. In Saccharomyces cerevisiae, the Kinesin-14 Kar3 forms a heterodimer with either Vik1 or Cik1. Vik1 contains a motor homology domain that retains microtubule binding properties but lacks a nucleotide binding site. In this case, both heads are implicated in motilit ...[more]