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The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy.

ABSTRACT: Cholesterol reduction from statin therapy has been one of the greatest public health successes in modern medicine. Simvastatin is among the most commonly used prescription medications. A non-synonymous coding single-nucleotide polymorphism (SNP), rs4149056, in SLCO1B1 markedly increases systemic exposure to simvastatin and the risk of muscle toxicity. This guideline explores the relationship between rs4149056 (c.521T>C, p.V174A) and clinical outcome for all statins. The strength of the evidence is high for myopathy with simvastatin. We limit our recommendations accordingly.

SUBMITTER: Wilke RA

PROVIDER: S-EPMC3384438 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature

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The clinical pharmacogenomics implementation consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy.

Wilke R A RA Ramsey L B LB Johnson S G SG Maxwell W D WD McLeod H L HL Voora D D Krauss R M RM Roden D M DM Feng Q Q Cooper-Dehoff R M RM Gong L L Klein T E TE Wadelius M M Niemi M M

Clinical pharmacology and therapeutics 20120523 1

Cholesterol reduction from statin therapy has been one of the greatest public health successes in modern medicine. Simvastatin is among the most commonly used prescription medications. A non-synonymous coding single-nucleotide polymorphism (SNP), rs4149056, in SLCO1B1 markedly increases systemic exposure to simvastatin and the risk of muscle toxicity. This guideline explores the relationship between rs4149056 (c.521T>C, p.V174A) and clinical outcome for all statins. The strength of the evidence ...[more]

PMID: 22617227

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