Ontology highlight
ABSTRACT:
SUBMITTER: Wilke RA
PROVIDER: S-EPMC3384438 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Clinical pharmacology and therapeutics 20120523 1
Cholesterol reduction from statin therapy has been one of the greatest public health successes in modern medicine. Simvastatin is among the most commonly used prescription medications. A non-synonymous coding single-nucleotide polymorphism (SNP), rs4149056, in SLCO1B1 markedly increases systemic exposure to simvastatin and the risk of muscle toxicity. This guideline explores the relationship between rs4149056 (c.521T>C, p.V174A) and clinical outcome for all statins. The strength of the evidence ...[more]