Increased intestinal lipid absorption caused by Ire1? deficiency contributes to hyperlipidemia and atherosclerosis in apolipoprotein E-deficient mice.

ABSTRACT: High fasting serum lipid levels are significant risk factors for atherosclerosis. However, the contributions of postprandial excursions in serum lipoproteins to atherogenesis are less well-characterized.This study aims to delineate whether changes in intestinal lipid absorption associated with loss of inositol-requiring enzyme 1? (Ire1?) would affect the development of hyperlipidemia and atherosclerosis in Apoe(-/-) mice.We used Ire1?-deficient mice to assess the contribution of intestinal lipid absorption to atherosclerosis. Here, we show that Ire1b(-/-)/Apoe(-/-) mice contain higher levels of intestinal microsomal triglyceride transfer protein, absorb more lipids, exhibit hyperlipidemia, and have higher levels of atherosclerotic plaques compared with Apoe(-/-) mice when fed chow and western diets.These studies indicate that Ire1? regulates intestinal lipid absorption and that increased intestinal lipoprotein production contributes to atherosclerosis.

SUBMITTER: Iqbal J 

PROVIDER: S-EPMC3384494 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature