Ontology highlight
ABSTRACT:
SUBMITTER: Park JG
PROVIDER: S-EPMC5474748 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Park Jong-Gil JG Yoo Ji-Young JY Jeong Se-Jin SJ Choi Jae-Hoon JH Lee Mi-Ran MR Lee Mi-Ni MN Hwa Lee Jeong J Kim Hyoung Chin HC Jo Hanjoong H Yu Dae-Yeul DY Kang Sang Won SW Rhee Sue Goo SG Lee Mun-Han MH Oh Goo Taeg GT
Circulation research 20110811 7
<h4>Rationale</h4>Peroxiredoxin 2 (Prdx2), a thiol-specific peroxidase, has been reported to regulate proinflammatory responses, vascular remodeling, and global oxidative stress.<h4>Objective</h4>Although Prdx2 has been proposed to retard atherosclerosis development, no direct evidence and mechanisms have been reported.<h4>Methods and results</h4>We show that Prdx2 is highly expressed in endothelial and immune cells in atherosclerotic lesions and blocked the increase of endogenous H(2)O(2) by at ...[more]